Physical Education
Hossein TaheriChadorneshin; Mohammad Esmaiel Afzalpour; Ehsan Afroozi-Gerow; Seyed Hosein Abtahi-Eivary; Meysam Alipour-Raz
Volume 26, Issue 1 , March and April 2019, , Pages 99-107
Abstract
Reactive oxygen species (ROS) result in serious damage oxidation of proteins, lipids and genomic structures. Studies have shown that production of ROS increases during intensive exercise training. The aim of present study was to investigate the effect of two type sprint and endurance exercise trainings ...
Read More
Reactive oxygen species (ROS) result in serious damage oxidation of proteins, lipids and genomic structures. Studies have shown that production of ROS increases during intensive exercise training. The aim of present study was to investigate the effect of two type sprint and endurance exercise trainings on 8-oxoguanine DNA glycosylase (OGG1) and hydroxy-2'-deoxyguanosine (8-OHdG) levels in the brain and liver of Wistar rats. 24 adult Albino Wistar rats were randomly divided into sedentary control, sprint exercise training, and endurance exercise training groups. Rats in sprint and endurance exercise training groups ran on treadmill for 6 weeks, 6 days per week, at 80 to 100 percent of maximal oxygen consumption. OGG1 and 8-OHdG levels were measured using sandwich ELISA assay. Data analyzed using one way ANOVA at P≤0.05 level. Results showed that both of sprint and endurance exercise trainings result in significant increase in OGG1 levels in brain and liver. Sprint exercise training resulted in greater increase in brain OGG1 than endurance exercise training. However, sprint and endurance exercise training had no significant effect on 8-OHdG levels in brain and liver tissues. OGG1 content correlated negatively with 8-OHdG levels. Collectively, sprint and endurance exercise trainings prevents from genomic structure through an increase in OGG1 contents.